HORDB

ID: hor002345
Uniprot ID: P17685
Protein name: Egg-laying hormone
Gene name: ELH1
Organism: Aplysia parvula (Dwarf sea hare)
Family: Molluscan ELH family
Source: Animal
Expression: Bag cell neurons.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: ISINQDLKAIADMLIVEQKQEREKYLADLRQRLLNK
Length: 36(198-233)
Propeptide: MGRPSYRSAAAISLLMCLILSALCASSESAVVHGSSFATERAVKSSPYLVLSPADEMVGMSTANEAFDKSPSYYDDDDDDFVKNEKRRLRFHKRRIRFNKRPQEVSGLKPVMMSRASASADENSLFDLYNTDGAMYQRDLRAPRLRFYSLRKRAAGDEDKSEENNPETESHSRRKRSALTPSIRSLRSSLESGIAKRISINQDLKAIADMLIVEQKQEREKYLADLRQRLLNKGKRSSEVALAASDKGDEERELL
Signal peptide: MGRPSYRSAAAISLLMCLILSALCASSES
Modification: T36 Lysine amide
Glycosylation: NA
Mutagenesis: NA

Function: ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs. It specifically causes contraction of smooth muscle in the ovotestis a
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002345_AF2.pdb

hor002345_ESM.pdb

Mass:	492254	Formula:	C188H323N55O57S
Absent amino acids:	CFGHPTW	Common amino acids:	L
pI:	9.19	Basic residues:	7
Polar residues:	4	Hydrophobic residues:	14
Hydrophobicity:	-58.06	Boman Index:	-9151
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	124.72
Instability Index:	3810	Extinction Coefficient cystines:	1490
Absorbance 280nm:	42.57